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Batefenterol
CAS No. 743461-65-6
Batefenterol( GSK961081 | TD-5959 )
Catalog No. M15839 CAS No. 743461-65-6
A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 149 | In Stock |
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| 5MG | 91 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 275 | In Stock |
|
| 50MG | 417 | In Stock |
|
| 100MG | 603 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBatefenterol
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NoteResearch use only, not for human use.
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Brief DescriptionA bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
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DescriptionA bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively; shows weak effect on β1; the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.COPD Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGSK961081 | TD-5959
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PathwayGPCR/G Protein
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TargetmAChR
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RecptorhM2|hM3|β2
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number743461-65-6
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Formula Weight740.2438
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Molecular FormulaC40H42ClN5O7
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESO=C(OC1CCNCC1)NC2=CC=CC=C2(CCC(NC3=CC(OC)=C(CNC[C@H](O)C4=CC=C(O)C5=C4C=CC(N5)=O)C=C3Cl)=O)C6=CC=CC=C6
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Chemical NameCarbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22.
2. Ambery C, et al. Drugs R D. 2015 Sep;15(3):281-91.
3. Ambery C, et al. Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407.
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