Cart
sales@molnova.com
Batefenterol
CAS No. 743461-65-6
Batefenterol( GSK961081 | TD-5959 )
Catalog No. M15839 CAS No. 743461-65-6
A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 88 | In Stock |
|
| 5MG | 133 | In Stock |
|
| 10MG | 205 | In Stock |
|
| 25MG | 385 | In Stock |
|
| 50MG | 574 | In Stock |
|
| 100MG | 803 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBatefenterol
-
NoteResearch use only, not for human use.
-
Brief DescriptionA bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
-
DescriptionA bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively; shows weak effect on β1; the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.COPD Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsGSK961081 | TD-5959
-
PathwayGPCR/G Protein
-
TargetmAChR
-
RecptorhM2|hM3|β2
-
Research AreaInflammation/Immunology
-
IndicationCOPD
Chemical Information
-
CAS Number743461-65-6
-
Formula Weight740.2438
-
Molecular FormulaC40H42ClN5O7
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM
-
SMILESO=C(OC1CCNCC1)NC2=CC=CC=C2(CCC(NC3=CC(OC)=C(CNC[C@H](O)C4=CC=C(O)C5=C4C=CC(N5)=O)C=C3Cl)=O)C6=CC=CC=C6
-
Chemical NameCarbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22.
2. Ambery C, et al. Drugs R D. 2015 Sep;15(3):281-91.
3. Ambery C, et al. Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407.
molnova catalog
related products
-
TAK-071
TAK-071 (TAK071) is a novel potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells.
-
Carbachol
Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
-
AZD 9164
A novel highly potent, selective, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, 10-fold selectivity over M2 (pIC50=9.0).
