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Batefenterol

CAS No. 743461-65-6

Batefenterol( GSK961081 | TD-5959 )

Catalog No. M15839 CAS No. 743461-65-6

A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 149 In Stock
5MG 91 In Stock
10MG 148 In Stock
25MG 275 In Stock
50MG 417 In Stock
100MG 603 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Batefenterol
  • Note
    Research use only, not for human use.
  • Brief Description
    A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
  • Description
    A bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively; shows weak effect on β1; the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.COPD Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GSK961081 | TD-5959
  • Pathway
    GPCR/G Protein
  • Target
    mAChR
  • Recptor
    hM2|hM3|β2
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    743461-65-6
  • Formula Weight
    740.2438
  • Molecular Formula
    C40H42ClN5O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    O=C(OC1CCNCC1)NC2=CC=CC=C2(CCC(NC3=CC(OC)=C(CNC[C@H](O)C4=CC=C(O)C5=C4C=CC(N5)=O)C=C3Cl)=O)C6=CC=CC=C6
  • Chemical Name
    Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22. 2. Ambery C, et al. Drugs R D. 2015 Sep;15(3):281-91. 3. Ambery C, et al. Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407.
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