TAS-102( TAS102, TAS-102, TAS 102, Trifluridine/tipiracil hydrochloride )

Catalog No. M15805 CAS No. 733030-01-8

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Datasheet

HNMR

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Product Name

TAS-102
Note

Research use only, not for human use.
Brief Description

TAS-102 is an investigational drug candidate for metastatic colorectal Y. It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
Description

TAS-102 is an investigational drug candidate for metastatic colorectal Y. It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
In Vitro

——
In Vivo

Animal Model:Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells Dosage:150 mg/kg/day Administration:p.o.; twice a day for 14 daysResult:Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
Synonyms

TAS102, TAS-102, TAS 102, Trifluridine/tipiracil hydrochloride
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

733030-01-8
Formula Weight

575.32
Molecular Formula

C19H23Cl2F3N6O7
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

O=C1NC(C(C(F)(F)F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O.O=C3NC(C(Cl)=C(CN4C(CCC4)=N)N3)=O.[H]Cl
Chemical Name

4-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidin-2(1H)-one compound with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4-diol (1:1) hydrochloride

1.Nukatsuka M, et al. anticancer Res. 2015 Sep;35(9):4605-15.

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