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Ponalrestat
CAS No. 72702-95-5
Ponalrestat( ICI 128436 | MK-538 | Ponalrestat )
Catalog No. M15783 CAS No. 72702-95-5
ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 10MG | 37 | In Stock |
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| 25MG | 61 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePonalrestat
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NoteResearch use only, not for human use.
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Brief Descriptionponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice
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Descriptionponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice.
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In Vitro——
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In VivoAnimal Model:Adult female Sprague-Dawley ratsDosage:10, 50 mg/kg Administration:Orally; daily; 8 weeks Result:Reduced sorbitol accumulation.
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SynonymsICI 128436 | MK-538 | Ponalrestat
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PathwayEndocrinology/Hormones
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TargetReductase
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RecptorAldose reductase
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Research Area——
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Indication——
Chemical Information
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CAS Number72702-95-5
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Formula Weight391.19
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Molecular FormulaC17H12BrFN2O3
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESO=C(O)CC1=NN(CC2=CC=C(Br)C=C2F)C(C3=C1C=CC=C3)=O
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Chemical Name2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pekiner C, McLean WG. Br J Pharmacol. 1990 Dec;101(4):978-80.
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