Cart
sales@molnova.com
Ponalrestat
CAS No. 72702-95-5
Ponalrestat( ICI 128436 | MK-538 | Ponalrestat )
Catalog No. M15783 CAS No. 72702-95-5
ponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
|
| 10MG | 37 | In Stock |
|
| 25MG | 61 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePonalrestat
-
NoteResearch use only, not for human use.
-
Brief Descriptionponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice
-
Descriptionponalrestat, an aldose reductase inhibitor, activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice.
-
In Vitro——
-
In VivoAnimal Model:Adult female Sprague-Dawley ratsDosage:10, 50 mg/kg Administration:Orally; daily; 8 weeks Result:Reduced sorbitol accumulation.
-
SynonymsICI 128436 | MK-538 | Ponalrestat
-
PathwayEndocrinology/Hormones
-
TargetReductase
-
RecptorAldose reductase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number72702-95-5
-
Formula Weight391.19
-
Molecular FormulaC17H12BrFN2O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM
-
SMILESO=C(O)CC1=NN(CC2=CC=C(Br)C=C2F)C(C3=C1C=CC=C3)=O
-
Chemical Name2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Pekiner C, McLean WG. Br J Pharmacol. 1990 Dec;101(4):978-80.
molnova catalog
related products
-
Finasteride
Finasteride is an orally active testosterone 5-alpha-reductase inhibitor (Ki= 10 nM).
-
Ranirestat
Ranirestat (AS-3201) is an orally active and potent aldose reductase (AR) inhibitor with neuroprotective properties that ameliorates peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy.
-
VU 0364770
VU 0364770(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.
