Rifabutin( Ansamycin | LM-427 )

Catalog No. M15779 CAS No. 72559-06-9

A semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	30	In Stock
10MG	29	In Stock
25MG	40	In Stock
50MG	51	In Stock
100MG	73	In Stock
200MG	Get Quote	In Stock
500MG	221	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Rifabutin
Note

Research use only, not for human use.
Brief Description

A semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
Description

A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Bacterial Infection Approved(In Vitro):Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.
In Vitro

Rifabutin is primarily bactericidal antibiotic drug used to treat tuberculosis. Its effect on bacteria is based on the DNA-dependent RNA polymerase blocking drug rifamycin S., a semi-synthetic derivative. It is effective, for example, in highly resistant mycobacteria, Gram-positive bacteria (and some are effective against Gram-negative bacteria), but also against Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare. Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.
In Vivo

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Synonyms

Ansamycin | LM-427
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Endoplasmin|HSP90|RNApolymerase
Research Area

Infection
Indication

Bacterial Infection

Chemical Information

CAS Number

72559-06-9
Formula Weight

847.0047
Molecular Formula

C46H62N4O11
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1c2c(O)c(C)c3c(C4=O)c2C5=NC6(CCN(CC(C)C)CC6)NC5=C1NC(/C(C)=C/C=C/[C@@H]([C@H](O)[C@H]([C@@H](O)[C@H]([C@@H]([C@H](C)[C@@H](OC)/C=C/O[C@]4(O3)C)OC(C)=O)C)C)C)=O
Chemical Name

Spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d]imidazole-2,4'-piperidine]-5,10,26(3H,9H)-trione, 16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-, (9S,12E,14S,15R,16S,17R,18R,19