Sulfamethoxazole

Research use only, not for human use.

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic.

Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. Target: Antibacterial Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). (In Vitro):Sulfonamides are structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells. Bacterial resistance to sulfamethoxazole is caused by mutations in the enzymes involved in folic acid synthesis that prevent the drug from binding to it.

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NSC 147832 | Ro 4-2130

Autophagy

Autophagy

DHPS| FolC

Infection

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723-46-6

253.28

C10H11N3O3S

>98% (HPLC)

Ethanol: 23 mg/mL (90.8 mM); DMSO: 51 mg/mL (201.35 mM)

CC1=CC(NS(=O)(C2=CC=C(N)C=C2)=O)=NO1

4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years