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AZD1152-HQPA
CAS No. 722544-51-6
AZD1152-HQPA( Barasertib | AZD2811 )
Catalog No. M15765 CAS No. 722544-51-6
The active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 106 | In Stock |
|
| 50MG | 210 | In Stock |
|
| 100MG | 389 | In Stock |
|
| 500MG | 888 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD1152-HQPA
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NoteResearch use only, not for human use.
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Brief DescriptionThe active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM.
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DescriptionThe active product of AZD1152, a potent, selective inhibitor of Aurora B kinase with IC50 of 0.37 nM; displays >3,700-fol selectivity for Aurora B over Aurora A; potently inhibits the growth of human colon, lung, and hematologic tumor xenografts.
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In VitroCell Proliferation Assay.Cell Line:AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells.Concentration:0-100 nM. (Barasertib -HQPA)Incubation Time:48 h.Result:IC50 values ranged from 3 nM to 40 nM.
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In Vivo——
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SynonymsBarasertib | AZD2811
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAuroraA|AuroraB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number722544-51-6
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Formula Weight507.5599
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Molecular FormulaC26H30FN7O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=CC(F)=C1)CC2=CC(NC3=C4C=CC(OCCCN(CC)CCO)=CC4=NC=N3)=NN2
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Chemical Name1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Grundy M, et al. Mol Cancer Ther. 2010 Mar;9(3):661-72.
2. Mortlock AA, et al. J Med Chem. 2007 May 3;50(9):2213-24. Epub 2007 Mar 21.
3. Wilkinson RW, et al. Clin Cancer Res. 2007 Jun 15;13(12):3682-8.
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