BC-21( NSC 109268 | BC21 )

Catalog No. M15647 CAS No. 691005-38-6

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

BC-21
Note

Research use only, not for human use.
Brief Description

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.
Description

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM; decreases the viability of β-catenin overexpressing HCT116 colon cancer cells that harbor the β-catenin mutation, and inhibits the clonogenic activity of these cells; inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression in HCT116 cells.
In Vitro

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In Vivo

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Synonyms

NSC 109268 | BC21
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

——
Indication

——

Chemical Information

CAS Number

691005-38-6
Formula Weight

680.659
Molecular Formula

C32H36Cl2Cu2N2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

Di-μ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]dicopper

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Tian W, et al. Biochemistry. 2012 Jan 17;51(2):724-31. 2. Tian W, et al. J Biomol Screen. 2012 Apr;17(4):530-4. 3. Jain D, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):945-52.

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