Inh2-B1( STK1 inhibitor B1 )

Catalog No. M15641 CAS No. 690216-38-7

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Product Name

Inh2-B1
Note

Research use only, not for human use.
Brief Description

Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM.
Description

Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain; exhibits in vitro growth inhibition of MRSA, and in vivo protection in mice against the lethal MRSA challenge; down-regulates cell wall hydrolase genes and disrupts the biofilm formation of MRSA.
In Vitro

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In Vivo

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Synonyms

STK1 inhibitor B1
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

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Indication

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CAS Number

690216-38-7
Formula Weight

411.45
Molecular Formula

C19H13N3O4S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Methyl 5-oxo-3-(phenyl carbamoyl)-1-thioxo-4,5dihydro[1,3]thiazolo[3,4-a]quinazoline-8-carboxylate

1. Kant S, et al. Sci Rep. 2017 Jul 11;7(1):5067.

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