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Anagrelide
CAS No. 68475-42-3
Anagrelide( Agrelin | Agrylin | Anagrelide | Anagrelide | BL 4162A | Xagrid | Shire | Thromboreductin )
Catalog No. M15616 CAS No. 68475-42-3
Anagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 64 | In Stock |
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| 25MG | 102 | In Stock |
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| 50MG | 145 | In Stock |
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| 100MG | 213 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 551 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAnagrelide
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NoteResearch use only, not for human use.
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Brief DescriptionAnagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor.
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DescriptionAnagrelide is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor.
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In VitroCell Proliferation Assay Cell Line:Megakaryocytic and non-megakaryocytic cellsConcentration:0.05, 0.3, 1 μM Incubation Time:12-day Result:Inhibited only megakaryocytic cell growth at every concentration testedCell Cytotoxicity Assay Cell Line:GIST882 and GIST48 cell line Concentration:0.1, 1, 10, 100, 1000, 10000 nM Incubation Time:Result:Induced a cytotoxic effect in the GIST882 cell line (IC50= 16 nM), but was only weakly active in the GIST48 cell line.
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In VivoAnimal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model Dosage:5 mg/kg Administration:Twice daily; for 10 days Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
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SynonymsAgrelin | Agrylin | Anagrelide | Anagrelide | BL 4162A | Xagrid | Shire | Thromboreductin
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number68475-42-3
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Formula Weight256.09
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Molecular FormulaC10H7Cl2N3O
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESC1C2=C(C=CC(=C2Cl)Cl)NC3=NC(=O)CN31
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Chemical Name6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Ginkgolide J
Ginkgolide J has neuroprotective activity it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.
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BI 1015550
Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM. BI 1015550 has potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) with a good safety profile.
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Mirodenafil
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.The pharmacoki-netics of mirodenafil were not significantly altered by this concurrent administration. Mirodenafil (50 or 100 mg), obviously improved erectile function and was well tolerated in a representative population of Korean men with broad-spectrum ED of various etiologies and severities.
