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(Z)-4-Hydroxytamoxifen
CAS No. 68047-06-3
(Z)-4-Hydroxytamoxifen( trans-4-Hydroxytamoxifen )
Catalog No. M15596 CAS No. 68047-06-3
A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 359 | In Stock |
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| 100MG | 529 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name(Z)-4-Hydroxytamoxifen
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NoteResearch use only, not for human use.
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Brief DescriptionA major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
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DescriptionA major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; shows a 100-fold increased affinity for ER and approximately 100-times more potent than trans-tamoxifen in suppressing cell growth and plasminogen activator activity.
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In Vitro——
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In Vivo——
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Synonymstrans-4-Hydroxytamoxifen
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorER
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number68047-06-3
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Formula Weight387.5139
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Molecular FormulaC26H29NO2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESOC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
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Chemical NamePhenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Isopsoralenoside
Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.Psoralen (P), isopsoralen (IP), psoralenoside (PO) and Isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
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SR 19881
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).?
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Y134
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively.
