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PIK-90
CAS No. 677338-12-4
PIK-90( PIK90 | PIK 90 )
Catalog No. M15589 CAS No. 677338-12-4
PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 77 | In Stock |
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| 50MG | 132 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePIK-90
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NoteResearch use only, not for human use.
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Brief DescriptionPIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
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DescriptionPIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively; inhibits phosphorylation of Akt and S6, blocks the antiapoptotic protein Survivin and driving cell death in malignant glioma the clinical CDK1/2 inhibitor cooperated with roscovitine.
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In Vitro——
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In Vivo——
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SynonymsPIK90 | PIK 90
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα|PI3Kβ|PI3Kγ|PI3Kδ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number677338-12-4
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Formula Weight351.3593
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Molecular FormulaC18H17N5O3
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Purity>98% (HPLC)
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SolubilityDMSO: < 1 mg/mL
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SMILESO=C(NC1=NC2=C(C=CC(OC)=C2OC)C3=NCCN13)C4=CN=CC=C4
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Chemical Name3-Pyridinecarboxamide, N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
2. Niedermeier M, et al. Blood. 2009 May 28;113(22):5549-57.
3. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47.
4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
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