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Helenalin

CAS No. 6754-13-8

Helenalin( NSC 85236 )

Catalog No. M15580 CAS No. 6754-13-8

Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Helenalin
  • Note
    Research use only, not for human use.
  • Brief Description
    Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.
  • Description
    Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway; ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-κB signaling (53.7±14.1% NF-κB activity at 2.5 uM); suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.
  • In Vitro
    Western Blot Analysis Cell Line:Jurkat T cells Concentration:10 μM Incubation Time:20-120 minutes Result:Caused complete inhibition of NF-κB DNA binding after 80 minutes.
  • In Vivo
    Animal Model:Immature male ICR mice Dosage:25 mg/kg Administration:i.p.; 6 to 12 hours Result:Caused a rapid decrease in hepatic glutathione levels.
  • Synonyms
    NSC 85236
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6754-13-8
  • Formula Weight
    262.305
  • Molecular Formula
    C15H18O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (381.24 mM)
  • SMILES
    C[C@@H]1C[C@@H]2[C@H]([C@@H]([C@]3([C@H]1C=CC3=O)C)O)C(=C)C(=O)O2
  • Chemical Name
    3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Widen JC, et al. ACS Chem Biol. 2017 Jan 20;12(1):102-113. 2. Chen S, et al. Cell Death Dis. 2017 Mar 30;8(3):e2710. 3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11;12:93.
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