IU1-47( IU1-47 | IU1 47 | IU147 )

Catalog No. M15562 CAS No. 670270-31-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

IU1-47
Note

Research use only, not for human use.
Brief Description

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM.
Description

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
In Vitro

Western Blot Analysis Cell Line:Murine cortical primary neurons (DIV5) isolated from APPSwe/P301L transgenic animals Concentration:3 μM, 10 and 30 μM Incubation Time:48 hours Result:Significantly decreased Tau and phosphotau species Ser-202/Thr-205 levels. No change in USP14 protein level.
In Vivo

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Synonyms

IU1-47 | IU1 47 | IU147
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

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Indication

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CAS Number

670270-31-2
Formula Weight

330.856
Molecular Formula

C19H23ClN2O
Purity

>98% (HPLC)
Solubility

DMSO : 16.67 mg/mL 50.39 mM
SMILES

CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
Chemical Name

1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone

1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

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