Cefotiam hydrochloride

Research use only, not for human use.

Cefotiam hydrochloride is a second-generation cephalosporin antibiotic, has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Cefotiam hydrochloride is a second-generation cephalosporin antibiotic, has broad-spectrum activity against Gram-positive and Gram-negative bacteria, its bactericidal activity results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins.(In Vitro):Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849.Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL.(In Vivo):Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) hydrochloride can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys.

Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849.Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL.

Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) hydrochloride can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys. Animal Model:Female CF1/b mice with P. mirabilis xenograft Dosage:12.5, 25, 50, 100, 200, 400 and 800 mg/kg Administration:Subcutaneous injection; twice a day, for 5 days Result:Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.

Cefotiam Hydrochloride | Halospor | Pansporin | Cefotiam dihydrochloride | Hydrochloride, Cefotiam | SCE 963

GPCR/G Protein

Antibacterial

PBPs

Infection

——

66309-69-1

562.08

C18H23N9O4S3·HCl

>98% (HPLC)

Water: 10 mM

CN(C)CCN1C(=NN=N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CC4=CSC(=N4)N)SC2)C(=O)O.Cl.Cl

(6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years