San78-130( —— )

Catalog No. M15512 CAS No. 66018-45-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

San78-130
Note

Research use only, not for human use.
Brief Description

San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM.
Description

San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277; inhibits (>80%) only 6 kinases including ALK1, FLT3, FLT4, KDR, MEK2 and MKK6 in a panel of 342 kinases, shows weak inhibition for other ALK isotypes; suppresses the BMP9-induced Smad1/5 pathway by mainly inhibiting ALK1 in C2C12 cells, promotes angiogenesis in both endothelial tube formation and microfluidic chip based 3D angiogenesis assays.
In Vitro

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In Vivo

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Synonyms

——
Pathway

TGF-beta/Smad
Target

TGFBR
Recptor

TGFBR
Research Area

——
Indication

——

CAS Number

66018-45-9
Formula Weight

366.41
Molecular Formula

C19H26O7
Purity

>98% (HPLC)
Solubility

——
SMILES

OC1=CC(OC)=CC(CCC[C@@H]([C@H](O)C(CCC[C@H](C)O2)=O)O)=C1C2=O
Chemical Name

(3S,8S,9S)-8,9,16-Trihydroxy-14-methoxy-3-methyl-3,4,5,6,9,10,11,12-octahydro-1Hbenzo[c][1]oxacyclotetradecine-1,7(8H)-dione

1. Cho H, et al. J Med Chem. 2017 Feb 23;60(4):1495-1508.

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