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Tolbutamide
CAS No. 64-77-7
Tolbutamide( D 860 | NSC 23813 | NSC 87833 | U-2043 )
Catalog No. M15457 CAS No. 64-77-7
Tolbutamide is an inhibitor of potassium channel, used for type II diabetes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 38 | In Stock |
|
| 1G | 55 | In Stock |
|
Biological Information
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Product NameTolbutamide
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NoteResearch use only, not for human use.
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Brief DescriptionTolbutamide is an inhibitor of potassium channel, used for type II diabetes.
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DescriptionTolbutamide is an inhibitor of potassium channel, used for type II diabetes.
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In VitroWestern Blot Analysis Cell Line:Glioma cell Concentration:400 μM Incubation Time:24h Result:Increasing the level of Cx43.
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In VivoAnimal Model:Non-obese-diabetic mouse Dosage:125 mg/kg Administration:Supplemented in daily diet for 27 weeks Result:Showed 10 of 23 animals developed diabetes compared with 18 of 24 in the control groups.Animal Model:Pregnant mice Dosage:100 mg/kg, 400 mg/kg Administration:Intraperitoneal injection (i.p.) Result:Showed a significant reduction (50 %) in the frequency of living fetuses for the group of 400 mg/kg on day 13.
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SynonymsD 860 | NSC 23813 | NSC 87833 | U-2043
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number64-77-7
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Formula Weight270.35
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Molecular FormulaC12H18N2O3S
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Purity>98% (HPLC)
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SolubilityEthanol: 54 mg/mL warmed (199.74 mM); DMSO: 54 mg/mL (199.74 mM)
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SMILESO=C(NS(=O)(C1=CC=C(C)C=C1)=O)NCCCC
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Chemical Name1-butyl-3-(4-methylphenyl)sulfonylurea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wray HL, et al, Biochem Biophys Res Commun. 1973, 53(1), 291-294.
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