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L-Phenylalanine
CAS No. 63-91-2
L-Phenylalanine( —— )
Catalog No. M15427 CAS No. 63-91-2
L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
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| 200MG | 38 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | 45 | In Stock |
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Biological Information
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Product NameL-Phenylalanine
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NoteResearch use only, not for human use.
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Brief DescriptionL-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.
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DescriptionL-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM Target: Calcium Channel L-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins.(In Vitro):DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM.(In Vivo):The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.
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In VitroDAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine.L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM.
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In VivoThe effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM). L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCalcium Channel
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Recptorα2δ calcium channels
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number63-91-2
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Formula Weight165.19
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Molecular FormulaC9H11NO2
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Purity>98% (HPLC)
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SolubilityH2O: ≥ 46 mg/Ml
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SMILESN[C@@H](CC1=CC=CC=C1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mortell, K.H., et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett, 2006. 16(5): p. 1138-41.
2. Glushakov, A.V., et al., Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry, 2002. 7(4): p. 359-67.
3. Glushakov, A.V., et al., L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res, 2003. 72(1): p. 116-24.
4. Glushakov, A.V., et al., Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain, 2005. 128(Pt 2): p. 300-7.
5. Moller, H.E., et al., Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria. Pediatrics, 2003. 112(6 Pt 2): p. 1580-3.
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