CID-2011756( CID2011756 | CID 2011756 | CID-2011756 )

Catalog No. M15420 CAS No. 638156-11-3

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Product Name

CID-2011756
Note

Research use only, not for human use.
Brief Description

CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate Y cells.
Description

CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate Y cells.
In Vitro

CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 μM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 μM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 μM and 0.7±0.2 μM for PKD2 and PKD3, respectively.
In Vivo

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Synonyms

CID2011756 | CID 2011756 | CID-2011756
Pathway

Apoptosis
Target

Serine/threonin kinase
Recptor

PKD
Research Area

Cancer
Indication

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CAS Number

638156-11-3
Formula Weight

396.87
Molecular Formula

C22H21ClN2O3
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

O=C(C1=CC=C(C2=CC=CC(Cl)=C2)O1)NC3=CC=C(CN4CCOCC4)C=C3
Chemical Name

5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide

1.Sharlow ER, et al. PLoS One. 2011;6(10):e25134.

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