(R)-Baclofen hydrochloride( STX-209 hydrochloride )

Catalog No. M15416 CAS No. 63701-55-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

(R)-Baclofen hydrochloride
Note

Research use only, not for human use.
Brief Description

A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist; also blocks α2δ subunit-containing voltage-dependent calcium channel (VDCC) with Ki of 156 uM.
Description

A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist; also blocks α2δ subunit-containing voltage-dependent calcium channel (VDCC) with Ki of 156 uM; A neurotransmitter inhibitor by blocking the release of excitatory transmitters; serves as a central nervous system depressant and skeletal muscle relaxant.
In Vitro

——
In Vivo

(R)-Baclofen hydrochloride (STX 209 hydrochloride) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg.Acute intraperitoneal administration of (R)-Baclofen hydrochloride significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg.
Synonyms

STX-209 hydrochloride
Pathway

Membrane Transporter/Ion Channel
Target

GAT
Recptor

GAT
Research Area

Other Indications
Indication

Other Disease

CAS Number

63701-55-3
Formula Weight

250.1217
Molecular Formula

C10H13Cl2NO2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

c1cc(ccc1[C@@H](CC(=O)O)CN)Cl.Cl
Chemical Name

Benzenepropanoic acid, β-(aminomethyl)-4-chloro-, hydrochloride (1:1), (βR)-

1. Zvejniece L, et al. Pharmacol Biochem Behav. 2015 Oct;137:23-9. 2. Carter LP, et al. Pharmacol Ther. 2009 Jan;121(1):100-14.

Calculator

molnova catalog