Mosapride citrate dihydrate( AS-4370 citrate | TAK-370 )

Catalog No. M15413 CAS No. 636582-62-2

Mosapride citrate (AS-4370 citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	88	Get Quote
100MG	Get Quote	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

Mosapride citrate dihydrate
Note

Research use only, not for human use.
Brief Description

Mosapride citrate (AS-4370 citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
Description

Mosapride citrate (AS-4370 citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist; accelerates gastric emptying throughout the whole of the gastrointestinal tract invivo, and is used for the treatment of gastritis, gastro-oesophageal reflux disease, functional dyspepsia and irritable bowel syndrome.Other Indication Phase 2 Clinical.
In Vitro

Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC50 of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials.
In Vivo

Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility. Animal Model:Beagle dogsDosage:0.3-3 mg/kgAdministration:Intravenous injection; 0.3-3 mg/kg Result:Increased the antral motor activity dose-dependently in conscious dogs.
Synonyms

AS-4370 citrate | TAK-370
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

Other Indications
Indication

Other Disease

Chemical Information

CAS Number

636582-62-2
Formula Weight

614.02
Molecular Formula

C27H33ClFN3O10
Purity

>98% (HPLC)
Solubility

——
SMILES

CCOC1=CC(=C(C=C1C(=O)NCC2CN(CCO2)CC3=CC=C(C=C3)F)Cl)N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O.O
Chemical Name

4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide citrate

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kato S, et al. J Med Chem. 1991 Feb;34(2):616-24. 2. Yoshida N, et al. J Pharmacol Exp Ther. 1991 May;257(2):781-7. 3. Sakashita M, et al. Arzneimittelforschung. 1993 Aug;43(8):859-63.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks