Closantel sodium( —— )

Catalog No. M15316 CAS No. 61438-64-0

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Product Name

Closantel sodium
Note

Research use only, not for human use.
Brief Description

A veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases.
Description

A veterinary anthelmintic with known proton ionophore activities; is identified as a potent and specific inhibitor of filarial chitinases; also shows to be an allosteric inhibitor of SPAK and OSR1.Parasite Infection Approved(In Vitro):Closantel sodium, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
In Vitro

Closantel sodium, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase.
In Vivo

——
Synonyms

——
Pathway

Microbiology/Virology
Target

Parasite
Recptor

Others
Research Area

Infection
Indication

Parasite Infection

CAS Number

61438-64-0
Formula Weight

685.0555
Molecular Formula

C22H13Cl2I2N2NaO2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=CC(=C(C=C1NC(=O)C2=C(C(=CC(=C2)I)I)O)Cl)C(C#N)C3=CC=C(C=C3)Cl.[Na]
Chemical Name

Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-, sodium salt (1:1)

1. AlAmri MA, et al. ChemMedChem. 2017 May 9;12(9):639-645. 2. Gloeckner C, et al. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3424-9.

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