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Rolipram

CAS No. 61413-54-5

Rolipram( SB95952 | ZK62711 | (R,S)-Rolipram | SB 95952 | ZK 62711 | SB-95952 | ZK-62711 )

Catalog No. M15314 CAS No. 61413-54-5

A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
10MG 41 In Stock
50MG 57 In Stock
100MG 81 In Stock
200MG 119 In Stock
500MG 197 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Rolipram
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
  • Description
    A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.Asthma Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB95952 | ZK62711 | (R,S)-Rolipram | SB 95952 | ZK 62711 | SB-95952 | ZK-62711
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE4B|PDE4D
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    61413-54-5
  • Formula Weight
    275.3428
  • Molecular Formula
    C16H21NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 41 mg/mL
  • SMILES
    O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
  • Chemical Name
    2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8. 2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36. 3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
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