Cart
sales@molnova.com
Home - Products - Angiogenesis - PDE - Rolipram

Rolipram

CAS No. 61413-54-5

Rolipram( SB95952 | ZK62711 | (R,S)-Rolipram | SB 95952 | ZK 62711 | SB-95952 | ZK-62711 )

Catalog No. M15314 CAS No. 61413-54-5

A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
10MG 41 In Stock
50MG 57 In Stock
100MG 81 In Stock
200MG 119 In Stock
500MG 197 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Rolipram
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
  • Description
    A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.Asthma Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB95952 | ZK62711 | (R,S)-Rolipram | SB 95952 | ZK 62711 | SB-95952 | ZK-62711
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE4B|PDE4D
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    61413-54-5
  • Formula Weight
    275.3428
  • Molecular Formula
    C16H21NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 41 mg/mL
  • SMILES
    O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
  • Chemical Name
    2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8. 2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36. 3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Propentofylline

    Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's disease, vascular dementia, cognitive impairment, dementia, and chronic pain.

  • Arofylline

    Arofylline is a PDE4 inhibitor and can be used for asthma studies.

  • CRT0273750

    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.

Sign In Join Free