FC131( FC 131 | cyclo(-D-Tyr-Arg-Arg-Nal-Gly- )

Catalog No. M15275 CAS No. 606968-52-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

FC131
Note

Research use only, not for human use.
Brief Description

FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM.
Description

FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21 nM.
In Vitro

——
In Vivo

——
Synonyms

FC 131 | cyclo(-D-Tyr-Arg-Arg-Nal-Gly-
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

——
Indication

——

CAS Number

606968-52-9
Formula Weight

729.84
Molecular Formula

C36H47N11O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NCC(N[C@@H]1CC2=CC=C(O)C=C2)=O)[C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC3=CC(C=CC=C4)=C4C=C3
Chemical Name

1,1'-(((2S,5S,8S,14R)-14-(4-hydroxybenzyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecane-2,5-diyl)bis(propane-3,1-diyl))diguanidine

1. Tamamura H, et al. J Med Chem. 2005 Jan 27;48(2):380-91. 2. Thiele S, et al. Br J Pharmacol. 2014 Dec;171(23):5313-29.

Calculator

molnova catalog