Cart
sales@molnova.com
AZD-5438
CAS No. 602306-29-6
AZD-5438( AZD 5438 | AZD5438 )
Catalog No. M15245 CAS No. 602306-29-6
A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
|
| 5MG | 42 | In Stock |
|
| 10MG | 60 | In Stock |
|
| 25MG | 107 | In Stock |
|
| 50MG | 176 | In Stock |
|
| 100MG | 318 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAZD-5438
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro.
-
DescriptionA potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14 nM) and GSK-3β (IC50=17 nM) in vitro, displays 75-fold less active against cyclin D-Cdk4; shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7 uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle; inhibits the human tumor xenograft growth in vivo; also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a β-lactam-synergism-dependent manner.Solid Tumors Phase 1 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsAZD 5438 | AZD5438
-
PathwayCell Cycle/DNA Damage
-
TargetCDK
-
RecptorCDK1|CDK2|CDK9
-
Research AreaCancer
-
IndicationSolid Tumors
Chemical Information
-
CAS Number602306-29-6
-
Formula Weight371.4566
-
Molecular FormulaC18H21N5O2S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=S(C1=CC=C(NC2=NC=CC(C3=CN=C(C)N3C(C)C)=N2)C=C1)(C)=O
-
Chemical Name2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Byth KF, et al. Mol Cancer Ther. 2009 Jul;8(7):1856-66.
2. Boss DS, et al. Ann Oncol. 2010 Apr;21(4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14.
molnova catalog
related products
-
AT-7519 hydrochlorid...
A potent CDK2 inhibitor with IC50 of 47 nM; also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM).
-
Flavopiridol
A potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
-
Palbociclib
A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM.
