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KU-55933
CAS No. 587871-26-9
KU-55933( KU 55933 | KU55933 )
Catalog No. M15169 CAS No. 587871-26-9
KU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 149 | In Stock |
|
| 100MG | 259 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKU-55933
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NoteResearch use only, not for human use.
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Brief DescriptionKU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM.
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DescriptionKU-55933 is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases; inhibits ATM-dependent p53 Ser15 phosphorylation in U2OS osteosarcoma cells with IC50 of 0.3 uM, sensitizes the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin; also suppresses the replication of both wild-type and drug-resistant HIV-1 by sensitizing cells to retrovirus-induced cell death.
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In Vitro——
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In Vivo——
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SynonymsKU 55933 | KU55933
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PathwayCell Cycle/DNA Damage
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TargetATM/ATR
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RecptorATM|ATR|DNA-PK|mTOR|PI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number587871-26-9
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Formula Weight395.4946
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Molecular FormulaC21H17NO3S2
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Purity>98% (HPLC)
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SolubilityDMSO: 80 mg/mL (Need ultrasonic)
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SMILESO=C1C=C(N2CCOCC2)OC(C3=C4SC5=C(C=CC=C5)SC4=CC=C3)=C1
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Chemical Name4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hickson I, et al. Cancer Res. 2004 Dec 15;64(24):9152-9.
2. Lau A, et al. Nat Cell Biol. 2005 May;7(5):493-500.
3. Soriani A, et al. Blood. 2009 Apr 9;113(15):3503-11.
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