Inosine

Research use only, not for human use.

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose.

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.(In Vitro):Inosine dose-dependently stimulates cAMP production mediated through the A2AR.Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.

Inosine dose-dependently stimulates cAMP production mediated through the A2AR.Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.

Animal Model:Male/female C57BL/6 mice Dosage:1 mg/kg, 10 mg/kg, 100 mg/kg Administration:Intraperitoneal injection, 20 min before formalin treatment Result:Reduced flinching behaviour induced by formalin (2 %; 20 μL; intraplantar injection).

Inosine | NSC 20262 | NSC-20262 | NSC20262

Immunology/Inflammation

ROS

XO

——

——

58-63-9

268.23

C10H12N4O5

>98% (HPLC)

Water: 47 mg/mL warmed (175.22 mM); DMSO: 53 mg/mL warmed (197.59 mM)

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)O)O1)O)O

Inosine

(-20℃)

With Ice Pack

≥ 2 years