GW 806742X( GW806742X )

Catalog No. M15127 CAS No. 579515-63-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GW 806742X
Note

Research use only, not for human use.
Brief Description

A small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM).
Description

A small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis; rescues 50% of wild-type MDFs from TSQ-induced necroptosis with IC50 <50 nM, with >50-fold greater potency than Nec-1; enhances RIPK3-mediated phosphorylation of MLKL (S345 and S347) at 10 uM.
In Vitro

GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner.?GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.
In Vivo

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Synonyms

GW806742X
Pathway

MAPK/ERK Signaling
Target

MLK
Recptor

MLK
Research Area

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Indication

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CAS Number

579515-63-2
Formula Weight

573.551
Molecular Formula

C25H22F3N7O4S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL 217.94 mM
SMILES

CN(C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)C3=NC(=NC=C3)NC4=CC(=CC=C4)S(=O)(=O)N
Chemical Name

3-((4-(methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide

1. Hildebrand JM, et al. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7.

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