Stevioside( Steviosin | CCRIS 6116 )

Catalog No. M15116 CAS No. 57817-89-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Stevioside
Note

Research use only, not for human use.
Brief Description

A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose.
Description

A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference.
In Vitro

Apoptosis Analysis Cell Line:MDA-MB-231 Concentration:10 μM Incubation Time:24 h Result:Increased the rate of apoptosis in cells with combination of 5-Fu (HY-90006).Increased ROS level significantly in MDA-MB-231. Combinated with 5-Fu (HY-90006) could trigger early and late apoptotic events in cancer cells.Western Blot AnalysisCell Line:THP-1 cells Concentration:1 mM Incubation Time:45 min Result:Inhibited the expression level of NF-κB and IKKβ.
In Vivo

Animal Model:Balb/c miceDosage:6.25-25 mg/kg Administration:p.o., daily, 7 days Result:Didn’t show any change in the general behaviour of the test animals.Increased antibody synthesis of 15.38% and delayed type hypersensitivity (DTH) response of 18% at the dose of 12.5 mg/kg.
Synonyms

Steviosin | CCRIS 6116
Pathway

Others
Target

Other Targets
Recptor

TLR2
Research Area

Metabolic Disease
Indication

——

CAS Number

57817-89-7
Formula Weight

804.88
Molecular Formula

C38H60O18
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

C=C([C@@](CC1)(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C4)C[C@@]54CC[C@]6([H])[C@@](C(O[C@H]7[C@@H]([C@H]([C@@H]([C@@H](CO)O7)O)O)O)=O)(C)CCC[C@@]6(C)[C@@]51[H]
Chemical Name

(4alpha)-beta-D-Glucopyranosyl 13-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)kaur-16-en-18-oate

1.Wang T, et al. Int Immunopharmacol. 2014 Sep;22(1):192-9.

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