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ML-60218
CAS No. 577784-91-9
ML-60218( ML60218 )
Catalog No. M15113 CAS No. 577784-91-9
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 120 | In Stock |
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| 5MG | 110 | In Stock |
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| 10MG | 178 | In Stock |
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| 25MG | 390 | In Stock |
|
| 50MG | 593 | In Stock |
|
| 100MG | 844 | In Stock |
|
| 200MG | 1135 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML-60218
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NoteResearch use only, not for human use.
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Brief DescriptionML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
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DescriptionML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively; compromises the structural integrity of viroplasms and rotavirus double-layered particles, interferes with the formation of higher order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize.
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In Vitro——
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In Vivo——
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SynonymsML60218
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number577784-91-9
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Formula Weight452.368
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Molecular FormulaC19H15Cl2N3O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (221.05 mM)
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SMILESO=S(C1=CC=CC=C1Cl)(NC2=CC(C3=C(C)C4=CC(Cl)=CC=C4S3)=NN2C)=O
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Chemical Name2-chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Eichwald C, et al. J Virol. 2017 Nov 15. pii: JVI.01943-17.
2. Wu L, et al. Eukaryot Cell. 2003 Apr;2(2):256-64.
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