Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - ML-60218

ML-60218

CAS No. 577784-91-9

ML-60218( ML60218 )

Catalog No. M15113 CAS No. 577784-91-9

ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 120 In Stock
5MG 110 In Stock
10MG 178 In Stock
25MG 390 In Stock
50MG 593 In Stock
100MG 844 In Stock
200MG 1135 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ML-60218
  • Note
    Research use only, not for human use.
  • Brief Description
    ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
  • Description
    ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively; compromises the structural integrity of viroplasms and rotavirus double-layered particles, interferes with the formation of higher order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ML60218
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    577784-91-9
  • Formula Weight
    452.368
  • Molecular Formula
    C19H15Cl2N3O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (221.05 mM)
  • SMILES
    O=S(C1=CC=CC=C1Cl)(NC2=CC(C3=C(C)C4=CC(Cl)=CC=C4S3)=NN2C)=O
  • Chemical Name
    2-chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Eichwald C, et al. J Virol. 2017 Nov 15. pii: JVI.01943-17. 2. Wu L, et al. Eukaryot Cell. 2003 Apr;2(2):256-64.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • HALOFUGINONE LACTATE

    HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM.?Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.?HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity;?this inhibition is reversed by the addition of exogenous proline or EPRS.

  • Vidarabine

    Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses.

  • DHX9-IN-2

    DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.

Sign In Join Free