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LASV inhibitor 3.3
CAS No. 554438-52-7
LASV inhibitor 3.3( LAMP1 inhibitor 3.3 )
Catalog No. M15014 CAS No. 554438-52-7
LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 82 | In Stock |
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| 25MG | 167 | In Stock |
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| 50MG | 270 | In Stock |
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| 100MG | 387 | In Stock |
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| 200MG | 541 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLASV inhibitor 3.3
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NoteResearch use only, not for human use.
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Brief DescriptionLASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM).
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DescriptionLASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits the GP-mediated infection of LCMV, LuJo virus (LUJV) or Junin virus (JUNV), Ebola virus (EBOV) or vesicular stomatitis virus (VSV); inhibits LAMP1 binding to LASV GP, which is cholesterol-dependent and sensitive to 3.3 inhibition; LASV inhibitor 3.3 is a competitive inhibitor of cholesterol binding to LAMP1.
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In VitroWestern Blot Analysis Cell Line:293T LAMP1 KO cells expressing LASV GP-His and 293T pX459 cells Concentration:1 and 10 μM Incubation Time:1 hour Result:Inhibited the LASV GP binds to LAMP1.
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In Vivo——
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SynonymsLAMP1 inhibitor 3.3
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PathwayMicrobiology/Virology
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TargetArenavirus
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RecptorArenavirus
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Research Area——
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Indication——
Chemical Information
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CAS Number554438-52-7
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Formula Weight471.645
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Molecular FormulaC30H37N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (53.01 mM)
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SMILESC1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CNC(=O)C45CC6CC(C4)CC(C6)C5
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Chemical NameN-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)adamantane-1-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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LCMV gp33-41
LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.This is the H-2Db restricted epitope derived from the lymphocytic choreomeningitis virus (LCMV) glycoprotein gp 33; residues 33 to 41.
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Nucleoprotein 396-40...
Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen.
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LHF-535
LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM.
