Cart
sales@molnova.com
Embelin
CAS No. 550-24-3
Embelin( Embelic acid | Emberine | NSC-91874 )
Catalog No. M14989 CAS No. 550-24-3
Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 5MG | 31 | In Stock |
|
| 10MG | 46 | In Stock |
|
| 25MG | 77 | In Stock |
|
| 50MG | 141 | In Stock |
|
| 100MG | 237 | In Stock |
|
| 200MG | 352 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEmbelin
-
NoteResearch use only, not for human use.
-
Brief DescriptionEmbelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties.
-
DescriptionEmbelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties; specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1 uM); has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo; also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62 uM.(In Vitro):Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP.
-
In Vitro——
-
In Vivo——
-
SynonymsEmbelic acid | Emberine | NSC-91874
-
PathwayApoptosis
-
TargetIAP
-
Recptor5-Lipoxygenase|mPGES-1|XIAP
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number550-24-3
-
Formula Weight294.3859
-
Molecular FormulaC17H26O4
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
-
Chemical Name2,5-Cyclohexadiene-1,4-dione, 2,5-dihydroxy-3-undecyl-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.
2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15;662(1-3):63-9.
3. Lin Z, et al. Chem Biol. 2013 Feb 21;20(2):253-61.
molnova catalog
related products
-
Birinapant
Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2.
-
MX107
MX107 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 3.1 uM.
-
APG-1387
APG-1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP).
