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D715-2441

CAS No. 54245-10-2

D715-2441( D 715-2441 )

Catalog No. M14943 CAS No. 54245-10-2

D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    D715-2441
  • Note
    Research use only, not for human use.
  • Brief Description
    D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein.
  • Description
    D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM; does not inhibit both viral entry and release, disrupts early influenza A virus replication, reduces vRNP activity and affects PB2 protein localization; shows binding affinity to influenza PB2cap protein with Kd of 0.118 uM; demonstrates a remarkable synergistic antiviral effect (FICI value of 0.40) combined with zanamivir.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    D 715-2441
  • Pathway
    Microbiology/Virology
  • Target
    Influenza Virus
  • Recptor
    Influenza Virus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    54245-10-2
  • Formula Weight
    228.203
  • Molecular Formula
    C13H8O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C2C(=C1)C3=C(C=C(C=C3OC2=O)O)O
  • Chemical Name
    1,3-dihydroxy-6H-benzo[c]chromen-6-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu T, et al. Mol Pharm. 2018 Aug 23. doi: 10.1021/acs.molpharmaceut.8b00531.
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