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Tranilast
CAS No. 53902-12-8
Tranilast( MK-341 | SB-252218 )
Catalog No. M14924 CAS No. 53902-12-8
A compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 32 | Get Quote |
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| 10MG | 45 | Get Quote |
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| 25MG | 55 | Get Quote |
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| 100MG | 110 | Get Quote |
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| 200MG | 167 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTranilast
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NoteResearch use only, not for human use.
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Brief DescriptionA compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
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DescriptionA compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells; inhibits endotoxin-induced PGE2 (IC50=1-20 uM), thromboxane B2 (IC50= 10-50 uM), TGF-β1 (IC50=100-200 uM), and IL-8 (IC50=100 uM) formation, but has no effect on TNF-α; also inhibits VEGF-induced angiogenetic activities.Allergy Approved.
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In VitroCell Proliferation Assay Cell Line:MCF-7 and MDA-MB-231 cells Concentration:10, 20, 50, 100, and 200 μMIncubation Time:48 hours Result:Anti-proliferative effect in a dose-dependent manner in both cell lines.Cell Viability Assay Cell Line:Human dermal microvascular endothelial cells (HDMECs) Concentration:12.5, 25, 50, 100 μg/mL Incubation Time:72 hours Result:IC50 value was 44.3 μg/mL (136 μM).
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In VivoAnimal Model:Nine-week-old male C57BL/6 miceDosage:300 mg/kg Administration:Administered orally twice a day for 3 days Result:Suppressed the VEGF-induced angiogenesis in matrigel; 58% of significant suppression was observed at a dose of 300 mg/kg. The ED50 value and 95% confidence limits were 165 mg/kg and 162±169 mg/kg, respectively.
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SynonymsMK-341 | SB-252218
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number53902-12-8
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Formula Weight327.3
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Molecular FormulaC18H17NO5
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Purity>98% (HPLC)
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SolubilityDMSO: 32.7 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCOC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
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Chemical NameBenzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Fenoprofen Calcium
Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.
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PKC ζ pseudosubstrat...
Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.
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Thianthrene
Thianthrene is a sulfur-containing heterocyclic chemical compound that is a derivative of the parent heterocycle called dithiin and is easy to oxidize.
