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APR-246
CAS No. 5291-32-7
APR-246( PRIMA-1MET )
Catalog No. M14875 CAS No. 5291-32-7
APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 70 | In Stock |
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| 5MG | 64 | In Stock |
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| 10MG | 102 | In Stock |
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| 25MG | 206 | In Stock |
|
| 50MG | 360 | In Stock |
|
| 100MG | 639 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1293 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAPR-246
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NoteResearch use only, not for human use.
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Brief DescriptionAPR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity.
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DescriptionAPR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation; also restores the pro-apoptotic function to mutant TAp63γ and TAp73β in tumor cells but has less effect on TAp73α;induces mutant p53-dependent mitochondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3; inhibits tumor xenograft growth in vivo.Ovarian Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPRIMA-1MET
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PathwayApoptosis
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TargetMDM2-p53
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Recptorp53activator|TrxR1inhibitor
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Research AreaCancer
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IndicationOvarian Cancer
Chemical Information
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CAS Number5291-32-7
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Formula Weight199.25
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Molecular FormulaC10H17NO3
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Purity>98% (HPLC)
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SolubilityDMSO: 20mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1C(COC)(CO)N2CCC1CC2
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Chemical Name2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shen J, et al. Oncogene. 2008 Nov 20;27(51):6571-80.
2. Bykov VJ, et al. Oncogene. 2005 May 12;24(21):3484-91.
3. R?kaeus N, et al. Oncogene. 2010 Dec 9;29(49):6442-51.
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