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SCH 486757
CAS No. 524019-25-8
SCH 486757( SCH-486757 | SCH486757 )
Catalog No. M14851 CAS No. 524019-25-8
A novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSCH 486757
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
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DescriptionA novel potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors; effectively suppresses cough in guinea pig capsaicin cough model, without affect on inspiratory electromyogram amplitude.Other Indication Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsSCH-486757 | SCH486757
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number524019-25-8
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Formula Weight440.368
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Molecular FormulaC24H23Cl2N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESClC1=CC=CC=C1C(N2[C@@H]3CC[C@H]2C[C@](C4=NC=CC=N4)(O)C3)C5=CC=CC=C5Cl
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Chemical Name8-(bis(2-chlorophenyl)methyl)-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McLeod RL, et al. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20.
2. Woodcock A, et al. Lung. 2010 Jan;188 Suppl 1:S47-52.
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