(+)-Matrine

Research use only, not for human use.

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-Y effects, and action as a kappa opioid receptor and u-receptor agonist.

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-Y effects, and action as a kappa opioid receptor and u-receptor agonist.

Cell Viability Assay Cell Line:A549, SMMC-7721 cells Concentration:0-500 μg/mL for A549 cells, 0-1.5 mg/mL for SMMC-7721 cellsIncubation Time:24-72 h Result:Inhibited the growth of A549 and SMMC-7721 cells.Western Blot AnalysisCell Line:A549, SMMC-7721 cells Concentration:100-250 μg/mL for A549 cells, 0.5-1 mg/mL for SMMC-7721 cellsIncubation Time:24 h Result:Down-regulated the expression of anti-apoptotic protein (Bcl-2) and up-regulated the level of pro-apoptotic protein (bax).ImmunofluorescenceCell Line:HK2 cells Concentration:10 μM Incubation Time:48 h Result:Increased SIRT3 expression reduced under cisplatin stimuli.

Animal Model:Xenograft male C57BL/6mice model (LLC cells)Dosage:40 and 80 mg/kg for 16 consecutive days Administration:Intragastric administration Result:Inhibited tumors growth.Decreased the ratio of CD206+/F4/80+, promoted the expression of CD4+ and CD8+ T cells, and inhibited the expression of Th2 in tumor and spleen tissues. Animal Model:Cisplatin-induced acute kidney injury (AKI) mice model Dosage:5 mg/kg daily for 4 days Administration:Intraperitoneal injections Result:Attenuated tubular injury observed in AKI mice, including renal tubular necrosis,formation of tubular casts, cytoplasmic vacuoles and renal infiltrationof inflammatory cells in mice.Decreased serum levels of TNF-a and IL-6 and the phosphorylation of NF-κB, activated SIRT3/OPA1 axis and improved mitochondrial function.

NSC 146051 | NSC 318810

Endocrinology/Hormones

Opioid Receptor

κ-opioid receptor

Cancer

——

519-02-8

248.37

C15H24N2O

>98% (HPLC)

Ethanol: 49 mg/mL (197.29 mM); Water: 11 mg/mL warmed (44.29 mM); DMSO: 49 mg/mL (197.29 mM)

O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@H]([C@@H]34)CN12

(41S,7aS,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one

(-20℃)

With Ice Pack

≥ 2 years