SP 4206( SP4206 )

Catalog No. M14795 CAS No. 515846-21-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SP 4206
Note

Research use only, not for human use.
Brief Description

SP 4206 is a high-affinity (Kd=70 nM) small molecule that blocks blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.
Description

SP 4206 is a high-affinity (Kd=70 nM) small molecule that blocks blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2; targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Rα.
In Vitro

SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC50s of 68.8, 80.1, 117.0, and 10.4 nM, respectively.
In Vivo

——
Synonyms

SP4206
Pathway

Apoptosis
Target

IL Receptor
Recptor

Interleukin Receptor
Research Area

——
Indication

——

CAS Number

515846-21-6
Formula Weight

662.57
Molecular Formula

C30H37Cl2N7O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (150.93 mM)
SMILES

O=C(C1=CC=C(COC2=CC=C(C3=NN(C)C(C4CCN(C(CNC([C@H](/N=C(N)\N)CC(C)C)=O)=O)CC4)=C3)C(Cl)=C2Cl)O1)O
Chemical Name

5-[[2,3-dichloro-4-[5-[1-[2-[[(2R)-2-(diaminomethylideneamino)-4-methylpentanoyl]amino]acetyl]piperidin-4-yl]-1-methylpyrazol-3-yl]phenoxy]methyl]furan-2-carboxylic acid

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. Thanos CD, et al. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7.

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