Cart
sales@molnova.com
PHA-408
CAS No. 503555-55-3
PHA-408( PHA-767408 | PHA767408 | PHA 408 )
Catalog No. M14711 CAS No. 503555-55-3
A novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 262 | Get Quote |
|
| 50MG | 1152 | Get Quote |
|
| 100MG | 1746 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePHA-408
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.
-
DescriptionA novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1; inhibits LPS-induces TNF-α producton in PBMCs and HWB with IC50 of 20-30 nM, prevents IL-1β-induced IκBα phosphorylation in RASFs while sparing the JNK and p38 MAPK pathways and has no effect on IKK-2 phosphorylation; demonstrates target-specific anti-inflammatory activities in in vivo model of airway inflammation.
-
In Vitro——
-
In Vivo——
-
SynonymsPHA-767408 | PHA767408 | PHA 408
-
PathwayImmunology/Inflammation
-
TargetIκB kinase (IKK)
-
RecptorIκB kinase (IKK)
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number503555-55-3
-
Formula Weight560.03
-
Molecular FormulaC29H27ClFN7O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
-
Chemical Name8-[[[5-Chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
INH14
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
-
BOT-64
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compoundBOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB.?
-
BAY-985
BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 (IC50s: 123, 276, 311, and 7930 nM). BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3, IC50: 74 nM).
