Corticosterone( 17-deoxy Cortisol | 11β,21-DHP | NSC 9705 | 11β,21-dihydroxy Progesterone )

Catalog No. M14695 CAS No. 50-22-6

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Product Name

Corticosterone
Note

Research use only, not for human use.
Brief Description

Corticosterone is a sensitive inhibitor of monoamine transport.
Description

Corticosterone is a sensitive inhibitor of monoamine transport. (In Vitro):Corticosterone (100 nM; 30 min) via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.Corticosterone (CORT) (1 μM; 48 h) shows good immunosuppressive properties (functionally compromises maturation of BMDC), which impairs LPS-induced up-regulation of maturation-associated markers (MHC class II, B7.2, B7.1 and CD40).(In Vivo):Corticosterone results in a marked reduction in the ability of BMDC cells to prime naive CD8+ T cells in vivo.Corticosterone (0.03 or 1 mg/kg; s.c.; single) downregulates expression of BDNF mRNA in dentate gyrus and CA1 of rats.Corticosterone (2.6 mg/kg; in animal feedings; 8 days) restores ethanol intake and preference to approximately normal preoperative levels in adrenalectomy (ADX) rats.
In Vitro

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In Vivo

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Synonyms

17-deoxy Cortisol | 11β,21-DHP | NSC 9705 | 11β,21-dihydroxy Progesterone
Pathway

Endocrinology/Hormones
Target

GR
Recptor

Glucocorticoid Receptor
Research Area

Neurological Disease
Indication

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CAS Number

50-22-6
Formula Weight

346.46
Molecular Formula

C21H30O4
Purity

>98% (HPLC)
Solubility

Soluble in DMSO
SMILES

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Chemical Name

(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

1.Shyti R, et al. Exp Neurol. 2015 Jan;263:214-20.

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