EX 527 (Selisistat)( Selisistat )

Catalog No. M14668 CAS No. 49843-98-3

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Product Name

EX 527 (Selisistat)
Note

Research use only, not for human use.
Brief Description

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.
Description

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.(In Vitro):Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.(In Vivo):Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
In Vitro

Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.
In Vivo

Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
Synonyms

Selisistat
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

SIRT1
Research Area

Cancer
Indication

——

CAS Number

49843-98-3
Formula Weight

248.71
Molecular Formula

C13H13ClN2O
Purity

>98% (HPLC)
Solubility

DMSO:50 mg/mL (201.03 mM); Ethanol:18 mg/mL (72.37 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
Chemical Name

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

1.Solomon JM, et al. Mol Cell Biol, 2006, 26(1), 28-38.

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