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D77

CAS No. 497836-10-9

D77( D-77 )

Catalog No. M14665 CAS No. 497836-10-9

A potent inhibitor of HIV-1 integrase-LEDGF/p75 interaction; binds to IN and IN(T125A) with Kd of 5.81 and 15.2 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    D77
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of HIV-1 integrase-LEDGF/p75 interaction; binds to IN and IN(T125A) with Kd of 5.81 and 15.2 uM.
  • Description
    A potent inhibitor of HIV-1 integrase-LEDGF/p75 interaction; binds to IN and IN(T125A) with Kd of 5.81 and 15.2 uM; affects the HIV-1 IN nuclear distribution thus exhibiting antiretroviral activity.HIV Infection Preclinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    D-77
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    497836-10-9
  • Formula Weight
    596.4458
  • Molecular Formula
    C28H22BrNO7S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)C1=CC=C(COC2=CC(Br)=C(/C=C(SC(N3CC(C4=CC=CC=C4)=O)=O)/C3=O)C=C2OCC)C=C1
  • Chemical Name
    Benzoic acid, 4-[[5-bromo-4-[[2,4-dioxo-3-(2-oxo-2-phenylethyl)-5-thiazolidinylidene]methyl]-2-ethoxyphenoxy]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Du L, et al. Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-44. 2. Li P, et al. J Biomol Struct Dyn. 2011 Oct;29(2):311-23.
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