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DPH
CAS No. 484049-04-9
DPH( —— )
Catalog No. M14620 CAS No. 484049-04-9
A cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | Get Quote |
|
| 5MG | 68 | Get Quote |
|
| 10MG | 107 | Get Quote |
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| 25MG | 222 | Get Quote |
|
| 50MG | 438 | Get Quote |
|
| 100MG | 597 | Get Quote |
|
| 200MG | 870 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameDPH
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NoteResearch use only, not for human use.
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Brief DescriptionA cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM).
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DescriptionA cell-permeable, small-molecule c-Abl kinase activator with pEC50 of 6.1(EC50=794 nM); binds to the myristoyl binding site, also stimulates in vitro c-Abl phosphorylation; induces both pY245 (pEC50=5.6) and pY412 c-Abl phosphorylation; dose dependently induces Crk-L pY207 in KG-1 cells; the first small-molecule tool compound for c-Abl activation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcr-Abl
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RecptorBcr-Abl
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number484049-04-9
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Formula Weight336.3198
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Molecular FormulaC18H13FN4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1=CC=C(C=C1)N2C=C(C(=N2)C3=CC=C(C=C3)F)C4C(=O)NC(=O)N4
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Chemical Name2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yang J, et al. Chem Biol. 2011 Feb 25;18(2):177-86.
2. Cabigas EB, et al. J Cardiovasc Pharmacol Ther. 2015 Jan;20(1):93-103.
3. Grover P, et al. PLoS One. 2015 Jul 29;10(7):e0133590.
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