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Tivozanib
CAS No. 475108-18-0
Tivozanib( AV-951 | AV951 | AV 951 )
Catalog No. M14578 CAS No. 475108-18-0
A highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
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| 2MG | 32 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 72 | In Stock |
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| 25MG | 138 | In Stock |
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| 50MG | 234 | In Stock |
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| 100MG | 419 | In Stock |
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| 200MG | 617 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTivozanib
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
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DescriptionA highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3; also inhibits EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie2 (IC50=20-80 nM); inhibits VEGF-induced VEGFR-2 phosphorylation in endothelial cells (IC50=0.16 nM); p.o. active.Kidney Cancer Approved.
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In Vitro——
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In Vivo——
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SynonymsAV-951 | AV951 | AV 951
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PathwayAngiogenesis
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TargetVEGFR
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RecptorEphB2|PDGFRα|VEGFR1|VEGFR2|VEGFR3
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Research AreaCancer
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IndicationKidney Cancer
Chemical Information
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CAS Number475108-18-0
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Formula Weight454.8631
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Molecular FormulaC22H19ClN4O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2Cl
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Chemical NameUrea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakamura K, et al. Cancer Res. 2006 Sep 15;66(18):9134-42.
2. Eskens FA, et al. Clin Cancer Res. 2011 Nov 15;17(22):7156-63.
3. Momeny M, et al. Sci Rep. 2017 Apr 6;7:45954.
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