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Zaurategrast
CAS No. 455264-31-0
Zaurategrast( CDP-323 | CDP 323 | CDP323 )
Catalog No. M14541 CAS No. 455264-31-0
A potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 789 | Get Quote |
|
| 100MG | 1197 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameZaurategrast
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist.
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DescriptionA potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist, an ester prodrug of CT-7758; is developed for the treatment of multiple sclerosis.Multiple Sclerosis Phase 2 Discontinued.
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In VitroZaurategrast (CT7758) is a carboxylate containing α4β1/α4/β7 integrin antagonist.
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In Vivo——
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SynonymsCDP-323 | CDP 323 | CDP323
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number455264-31-0
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Formula Weight521.4057
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Molecular FormulaC26H25BrN4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(O)[C@@H](NC1=C(Br)C(C12CCCCC2)=O)CC3=CC=C(NC4=NC=CC5=C4C=NC=C5)C=C3
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Chemical NameL-Phenylalanine, N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-(2,7-naphthyridin-1-ylamino)- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bailey, et al. Current Immunology Reviews, 2012, 8, 135-1402. Wolf C, et al. PLoS One. 2013;8(3):e58438.
3. Chanteux H, et al. Drug Metab Dispos. 2014 Jan;42(1):153-61.
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