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IR415
CAS No. 452967-14-5
IR415( IR 415 | IR-415 )
Catalog No. M14538 CAS No. 452967-14-5
IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 40 | In Stock |
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| 5MG | 36 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 221 | In Stock |
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| 100MG | 328 | In Stock |
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| 200MG | 458 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIR415
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NoteResearch use only, not for human use.
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Brief DescriptionIR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression.
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DescriptionIR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease; exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells, selectively targets HBx in a concentration-dependent manner.
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In VitroHepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes.IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx.
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In Vivo——
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SynonymsIR 415 | IR-415
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PathwayMicrobiology/Virology
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TargetHBV
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RecptorHBV
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Research Area——
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Indication——
Chemical Information
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CAS Number452967-14-5
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Formula Weight296.34
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Molecular FormulaC13H14F2N4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (421.81 mM)
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SMILES——
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Chemical NameN-(2,4-difluorophenyl)-N'-[3-(1H-imidazol-1-yl) propyl] thiourea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ghosh S, et al. J Biol Chem. 2017 Jul 28;292(30):12577-12588.
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