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GW788388
CAS No. 452342-67-5
GW788388( GW 788388 | GW-788388 )
Catalog No. M14537 CAS No. 452342-67-5
A potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 56 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 91 | In Stock |
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| 25MG | 163 | In Stock |
|
| 50MG | 261 | In Stock |
|
| 100MG | 384 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 896 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGW788388
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay.
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DescriptionA potent, selective, and orally active TGF-β type I receptor (ALK5) inhibitor with IC50 of 18 nM in binding assay; displays excellent selectivity over a panel of kinases (AMPK, Chk1, PDK1, etc.); has an IC50 of 93 nM in TGF-β cellular assay; presents activity in a PAN-induced model of kidney fibrosis by inhibiting collagen IA1 mRNA at doses of 3 and 10 mg/kg u.i.d.
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In Vitro——
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In Vivo——
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SynonymsGW 788388 | GW-788388
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorALK5
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number452342-67-5
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Formula Weight425.4824
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Molecular FormulaC25H23N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 48 mg/mL
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SMILESO=C(NC1CCOCC1)C2=CC=C(C3=NC=CC(C4=CNN=C4C5=NC=CC=C5)=C3)C=C2
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Chemical NameBenzamide, 4-[4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gellibert F, et al. J Med Chem. 2006 Apr 6;49(7):2210-21.
2. Petersen M, et al. Kidney Int. 2008 Mar;73(6):705-15.
3. de Oliveira FL, et al. PLoS Negl Trop Dis. 2012;6(6):e1696.
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