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Necrostatin-1
CAS No. 4311-88-0
Necrostatin-1( Nec-1 )
Catalog No. M14462 CAS No. 4311-88-0
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 43 | In Stock |
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| 25MG | 71 | In Stock |
|
| 50MG | 107 | In Stock |
|
| 100MG | 166 | In Stock |
|
| 200MG | 245 | In Stock |
|
| 500MG | 411 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNecrostatin-1
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NoteResearch use only, not for human use.
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Brief DescriptionNecrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
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DescriptionNecrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
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In Vitro——
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In Vivo——
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SynonymsNec-1
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PathwayApoptosis
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TargetTNF
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RecptorRIP1
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number4311-88-0
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Formula Weight259.33
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Molecular FormulaC13H13N3OS
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Purity>98% (HPLC)
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SolubilityDMSO: 51 mg/mL warmed (196.66 mM)
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SMILESO=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S
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Chemical Name5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Han W, et al. Apoptosis. 2009 May;14(5):674-86.
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