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Sotrastaurin
CAS No. 425637-18-9
Sotrastaurin( AEB071 | AEB 071 | AEB-071 )
Catalog No. M14447 CAS No. 425637-18-9
A potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 95 | In Stock |
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| 5MG | 79 | In Stock |
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| 10MG | 138 | In Stock |
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| 25MG | 268 | In Stock |
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| 50MG | 436 | In Stock |
|
| 100MG | 625 | In Stock |
|
| 200MG | 872 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSotrastaurin
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
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DescriptionA potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes; displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM); inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness; prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.Blood Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAEB071 | AEB 071 | AEB-071
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PathwayAngiogenesis
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TargetPKC
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RecptorPKCα|PKCβ1|PKCδ|PKCη|PKCθ
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number425637-18-9
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Formula Weight438.4812
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Molecular FormulaC25H22N6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C(C1=CNC2=C1C=CC=C2)=C3C4=C5C=CC=CC5=NC(N6CCN(C)CC6)=N4)NC3=O
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Chemical Name1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Evenou JP, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801.
2. Wagner J, et al. J Med Chem. 2009 Oct 22;52(20):6193-6.
3. Budde K, et al. Am J Transplant. 2010 Mar;10(3):571-81.
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