Crocin( —— )

Catalog No. M14446 CAS No. 42553-65-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Crocin
Note

Research use only, not for human use.
Brief Description

General descriptionA highly unsaturared diterpene dicarboxylic acid ester found in saffron.
Description

General descriptionA highly unsaturared diterpene dicarboxylic acid ester found in saffron.
In Vitro

Cell Viability Assay Cell Line:HCT116 Concentration:0, 50, 100, 150, 200, 250, 300, 350, 400, and 450 μM Incubation Time:24 h Result:Weakened the cell vitality in a concentration-dependent manner.Apoptosis Analysis Cell Line:HCT116 Concentration:150, 200 μM Incubation Time:24 hResult:Facilitated apoptosis of HCT-116 cells in a concentration-dependent manner.Abated the colony number and downregulated the positive expression of Ki-67.Western Blot Analysis Cell Line:HCT116 Concentration:150, 200 μM Incubation Time:24 h Result:Decreased the levels of p-JAK2, p-STAT3, and p-ERK, as well as the ratios of p-JAK2/JAK2, p-STAT3/STAT3, and pERK/ERK.
In Vivo

Animal Model:Bleomycin-induced pulmonary fibrosis in rat Dosage:20 mg/kg Administration: p.o.Result:Reduced the expression of TLR4 and IL-10.Reduced the expression of TNF-α and TGF-β1.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Other Indications
Indication

——

CAS Number

42553-65-1
Formula Weight

976.96
Molecular Formula

C44H64O24
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)/C)/C)/C=C/C=C(/C(=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)\C
Chemical Name

——

1. Sapanidou V, et al. Theriogenology. 2015 Nov;84(8):1273-82.

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