Cart
sales@molnova.com
Home - Products - Others - Other Targets - SC 57461

SC 57461

CAS No. 423169-68-0

SC 57461( SC 57461A )

Catalog No. M14440 CAS No. 423169-68-0

A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 33 In Stock
5MG 55 In Stock
10MG 88 In Stock
25MG 179 In Stock
50MG 275 In Stock
100MG 403 In Stock
200MG 573 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SC 57461
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
  • Description
    A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM), no effect on production of the cyclooxygenase metabolite thromboxane B(2); orally active in vivo.Irritable Bowel Syndrome Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Fasted CD rats Dosage:0.01, 0.1, 1, and 10 mg/kg Administration:Orally administered Result:The ED50 values were 0.2 mg/kg at 1.0 h and 0.8 mg/kg at 3.0 h. A single dose of 10 mg/kg blocked LTB4 production 79% at 6 h, 67% at 18 h, and 44% at 24 h.
  • Synonyms
    SC 57461A
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    423169-68-0
  • Formula Weight
    363.88
  • Molecular Formula
    C20H25NO3.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (687.04 mM)
  • SMILES
    O=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1
  • Chemical Name
    3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Askonas LJ, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82. 2. Kachur JF, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7. 3. Penning TD, et al. J Med Chem. 2002 Aug 1;45(16):3482-90.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Nonapeptide-1

    Nonapeptide-1 can inhibit the synthesis of melanin which makes it of interest for treating certain skin conditions.?

  • Quercetin 3,5,3-trim...

    Quercetin 3,5,3'-trimethyl ether is a natural product.

  • TIC10

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.

Sign In Join Free